| Date | Opponent | Location | Buy Tickets |
|---|---|---|---|
| November 5, 2021 (Friday) | at Wayne State (ex) | Detroit, Mich. | |
| November 10, 2021 (Wednesday) | Buffalo | Ann Arbor, Mich. | Buy Tickets |
| November 13, 2021 (Saturday) | vs. Prairie View A&M | Washington, D.C. | Buy Tickets |
| November 16, 2021 (Tuesday) | Seton Hall | Ann Arbor, Mich. | Buy Tickets |
| November 19, 2021 (Friday) | vs. UNLV | Las Vegas, Nev. | Buy Tickets Code: UMHOOPS |
| November 21, 2021 (Sunday) | vs. Arizona or Wichita State | Las Vegas, Nev. | Buy Tickets Code: UMHOOPS |
| November 24, 2021 (Wednesday) | Tarleton State | Ann Arbor, Mich. | Buy Tickets |
| December 1, 2021 (Wednesday) | at North Carolina | Chapel Hill, N.C. | Buy Tickets |
| December 4, 2021 (Saturday) | San Diego State | Ann Arbor, Mich. | Buy Tickets |
| December 7, 2021 (Tuesday) | at Nebraska | Lincoln, Neb. | Buy Tickets |
| December 11, 2021 (Saturday) | Minnesota | Ann Arbor, Mich. | Buy Tickets |
| December 18, 2021 (Saturday) | Southern Utah | Ann Arbor, Mich. | Buy Tickets |
| December 21, 2021 (Tuesday) | Purdue Fort Wayne | Ann Arbor, Mich. | Buy Tickets |
| December 30, 2021 (Thursday) | at Central Florida | Orlando, Fla. | Buy Tickets |
| January 4, 2022 (Tuesday) | at Rutgers | Piscataway, N.J. | Buy Tickets |
| January 8, 2022 (Saturday) | Michigan State | Ann Arbor, Mich. | Buy Tickets |
| January 11, 2022 (Tuesday) | Purdue | Ann Arbor, Mich. | Buy Tickets |
| January 14, 2022 (Friday) | at Illinois | Champaign, Ill. | Buy Tickets |
| January 18, 2022 (Tuesday) | Maryland | Ann Arbor, Mich. | Buy Tickets |
| January 23, 2022 (Sunday) | at Indiana | Bloomington, Ind. | Buy Tickets |
| January 26, 2022 (Wednesday) | Northwestern | Ann Arbor, Mich. | Buy Tickets |
| January 29, 2022 (Saturday) | at Michigan State | East Lansing, Mich. | Buy Tickets |
| February 1, 2022 (Tuesday) | Nebraska | Ann Arbor, Mich. | Buy Tickets |
| February 5, 2022 (Saturday) | at Purdue | West Lafayette, Ind. | Buy Tickets |
| February 8, 2022 (Tuesday) | at Penn State | State College, Pa. | Buy Tickets |
| February 12, 2022 (Saturday) | Ohio State | Ann Arbor, Mich. | Buy Tickets |
| February 17, 2022 (Thursday) | at Iowa | Iowa City, Iowa | Buy Tickets |
| February 20, 2022 (Sunday) | at Wisconsin | Madison, Wis. | Buy Tickets |
| February 23, 2022 (Wednesday) | Rutgers | Ann Arbor, Mich. | Buy Tickets |
| February 27, 2022 (Sunday) | Illinois | Ann Arbor, Mich. | Buy Tickets |
| March 3, 2022 (Thursday) | Iowa | Ann Arbor, Mich. | Buy Tickets |
| March 6, 2022 (Sunday) | at Ohio State | Columbus, Ohio | Buy Tickets |
| March 9-13 | Big Ten Tournament | Indianapolis, Ind. | Buy Tickets |
